Background:
Innervation interacts with enteric immune responses. Chronic intestinal inflammation is associated with increased risk of colorectal cancer. We aimed to study potential extrinsic neuronal modulation of intestinal tumor development in a mouse model.
Methods:
Experiments were performed with male ApcMin/+ or wild type mice (4�weeks old, body weight approximately 20�g). Subgroups with subdiaphragmatic vagotomy (apcV/wtV), sympathetic denervation of the small intestine (apcS/wtS) or sham operated controls (apcC/wtC) were investigated (n?=?6-14 per group). Three months after surgical manipulation, 10�cm of terminal ileum were excised, fixed for 48�h in 4% paraformaldehyde and all tumors were counted and their area determined in mm2 (mean?�?standard error of the mean (SEM)). Whole mounts of the muscularis of terminal ileum and duodenum (internal positive control) were also stained for tyrosine hydroxylase to confirm successful sympathetic denervation.
Results:
Tumor count in ApcMin/+ mice was 62?�?8 (apcC), 46?�?11 (apcV) and 54?�?8 (apcS) which was increased compared to wildtype controls with 4?�?0.5 (wtC), 5?�?0.5 (wtV) and 5?�?0.6 (wtS; all p?Source: http://www.jeccr.com/content/34/1/39
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