Combo therapy with lower intensity statin may be an alternative to higher-intensity monotherapy for some patients

The recent American College of Cardiology and American Heart Association cholesterol guidelines recommend initiating moderate or high-intensity statin monotherapy for patients with low-density lipoprotein (LDL) cholesterol levels of 4.91 mmol/L or greater to reduce their risk for atherosclerotic cardiovacualr disease (ASCVD), the leading cause of death for both men and women in the United States. The challenge in clinical practice is that some patients do not respond to high-intensity statin monotherapy and adverse effects are common.

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