Toxoplasma Gondii Inhibits Mast Cell Degranulation By Suppressing Phospholipase Cy-mediated Ca2+ Mobilization

An estimated one-third of people around the world are infected by the parasite Toxoplasma gondii, a distant relative of the malaria parasite, although normally only persons with a weakened immune response show any symptoms. But how does T. gondii subvert immune defenses, enabling it to survive inside cells of its bird and mammal hosts? With new methods for the real-time imaging of single cells, David Holowka and his team from Cornell University, USA, obtained results that help to explain this trick: when T...

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