Feedback Loop Maintains Basal Cell Population

Notch - the protein that can help determine cell fate - maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein - TGF beta (transforming growth factor beta), said Baylor College of Medicine researchers in the journal Cell Stem Cell. "When basal cell homeostasis (or maintenance of a stable population) is disrupted, it may be part of the process that initiates prostate cancer," said Dr. Li Xin, assistant professor of molecular and cellular biology at BCM and a senior author of the report...

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