Targeted Tissues Identified By Tiny Brightly Shining Probes

Called BRIGHTs, the tiny probes described in the online issue of Advanced Materials, bind to biomarkers of disease and, when swept by an infrared laser, light up to reveal their location. Tiny as they are, the probes are exquisitely engineered objects: gold nanoparticles covered with molecules called Raman reporters, in turn covered by a thin shell of gold that spontaneously forms a dodecahedron. The Raman reporters are molecules whose jiggling atoms respond to a probe laser by scattering light at characteristic wavelengths...

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