Reducing liver protein SIRT1 levels to reduce risk of fatty liver disease and obesity

A new study led by Boston University School of Medicine (BUSM) demonstrates that the abnormal metabolism linked to obesity could be regulated in part by the interaction of two metabolic regulators, called the NAD-dependent deacetylase SIRT1 and fibroblast growth factor 21 (FGF21). Using experimental models, the researchers found that a lack of SIRT1 protein in the liver led to lower levels of a liver secreted protein FGF21, which resulted in an increased likelihood of developing fatty liver disease and obesity.

Source: http://feedproxy.google.com/~r/mnt/healthnews/~3/xI0rJsrUe5s/271563.php

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