Dysfunctional TGF-beta signaling contributes to Loeys-Dietz syndrome-associated aortic aneurysm

Patients with the connective tissue disorder Loeys-Dietz syndrome (LDS) are at high risk for aortic aneurysm. LDS results in the presence of missense mutations within either of the genes encoding receptors for TGF-?. LDS-associated mutations are predicted to reduce TGF-? signaling; however, aortic tissue samples from LDS patients indicate that TGF-? signaling may be enhanced.

Source: http://feedproxy.google.com/~r/mnt/healthnews/~3/m1Rol1UkKsk/270570.php

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