Source: http://feedproxy.google.com/~r/mnt/healthnews/~3/NIayzOvIt3M/267448.php
Wednesday, 16 October 2013
Structure of active coagulation factor XIII published - milestone on the way to safe anticoagulation
Zedira, in cooperation with the group of Prof. Gerhard Klebe in Marburg, reported the first crystal structure of coagulation factor XIII in the active conformation. The article is now published in Angewandte Chemie International Edition and provides a proprietary high-resolution structure of FXIIIa in complex with the inhibitor ZED1301 serving as lead structure. The data are of enormous value for structure based drug design. Direct acting Factor XIIIa-blockers may provide a novel and safe option for preventing thrombotic events...
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