Functional Characteristics Of Antitumor T Cells Change With Increasing Time After Therapeutic Transfer

Beneficial effect of genetically engineered antitumor T cells was transient. Functionality of T cells changed over time. Strategies are needed to sustain antitumor functionality. Scientists have characterized how the functionality of genetically engineered T cells administered therapeutically to patients with melanoma changed over time. The data, which are published in Cancer Discovery, a journal of the American Association for Cancer Research, highlight the need for new strategies to sustain antitumor T cell functionality to increase the effectiveness of this immunotherapeutic approach...

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