The Factor That Could Influence Future Breast Cancer Treatment

Australian scientists have shown in the laboratory how a 'transcription factor' causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. The research, which has significant implications for breast cancer treatment, is published December 27 in the open access journal PLOS Biology. Transcription factors are molecules that switch genes on or off. In this case, the transcription factor known as 'ELF5' inhibits sensitivity to estrogen very early in the life of a breast cancer cell...

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