Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood-stage antigens in Burkina Faso

Background:
HBB, IL4, IL12, TNF, LTA, NCR3 and FCGR2A polymorphisms have been associated withmalaria resistance in humans, whereas cytophilic immunoglobulin G (IgG) antibodies arethought to play a critical role in immune protection against asexual blood stages of theparasite. Furthermore, HBB, IL4, TNF, and FCGR2A have been associated with both malariaresistance and IgG levels. This suggests that some malaria resistance genes influence thelevels of IgG subclass antibodies.
Methods:
In this study, the effect of HBB, IL4, IL12, TNF, LTA, NCR3 and FCGR2A polymorphismson the levels of IgG responses against Plasmodium falciparum blood-stage extract wasinvestigated in 220 individuals living in Burkina Faso. The Pearson's correlation coefficientamong IgG subclasses was determined. A family-based approach was used to assess theassociation of polymorphisms with anti-P. falciparum IgG, IgG1, IgG2, IgG3 and IgG4levels.
Results:
After applying a multiple test correction, several polymorphisms were associated with IgGsubclass or IgG levels. There was an association of i) haemoglobin C with IgG levels; ii) theFcgammaRIIa H/R131 with IgG2 and IgG3 levels; iii) TNF-863 with IgG3 levels; iv) TNF-857with IgG levels; and, v) TNF1304 with IgG3, IgG4, and IgG levels.
Conclusion:
Taken together, the results support the hypothesis that some polymorphisms affect malariaresistance through their effect on the acquired immune response, and pave the way towardsfurther comprehension of genetic control of an individual's humoral response against malaria.

Source: http://www.malariajournal.com/content/11/1/308

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